Metabotropic GABAB Receptors
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منابع مشابه
GABAB receptor attenuation of GABAA currents in neurons of the mammalian central nervous system
Ionotropic receptors are tightly regulated by second messenger systems and are often present along with their metabotropic counterparts on a neuron's plasma membrane. This leads to the hypothesis that the two receptor subtypes can interact, and indeed this has been observed in excitatory glutamate and inhibitory GABA receptors. In both systems the metabotropic pathway augments the ionotropic re...
متن کاملRecent advances in GABA receptor biology have resulted in elucidation of the molecular structure of a GABAB protein with similarity to metabotropic
Julia H. White Fiona H. Marshall 7TMReceptor Systems, Molecular Pharmacology Dept, GlaxoWellcome Research and Development, Medicines Research Centre, Stevenage, Hertfordshire, UK SG1 2NY. Recent advances in GABA receptor biology have resulted in elucidation of the molecular structure of a GABAB protein with similarity to metabotropic glutamate receptors (mGluRs), GABAB(1) (Ref. 1), and the subs...
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Adult neurogenesis is tightly regulated through the interaction of neural stem/progenitor cells (NSCs) with their niche. Neurotransmitters, including GABA activation of GABAA receptor ion channels, are important niche signals. We show that adult mouse hippocampal NSCs and their progeny express metabotropic GABAB receptors. Pharmacological inhibition of GABAB receptors stimulated NSC proliferati...
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Activation of the metabotropic g-aminobutyric acidB (GABAB) receptor increases K conductance and decreases Ca channel activity in neuronal membranes. Studies with a number of new GABAB receptor agonists and antagonists reveal that in addition to their muscle relaxant effects, agonists display analgesic activity and reduce the craving for cocaine. With regard to GABAB receptor antagonists, precl...
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The metabotropic GABAB receptors mediate slow synaptic inhibition and consist of heterodimers of GABAB1 and GABAB2 subunits. The only known molecular diversity of the GABAB receptors arises from the two GABAB1 isoforms, but its functional significance has been unclear. Two studies in this issue of Neuron now demonstrate that GABAB1a and GABAB1b show strategically distinct subcellular localizati...
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تاریخ انتشار 2000